Systems Toxicology Informatics Post Doctoral Fellow

The Toxicology and Environmental Research & Consulting (TERC) function at The Dow Chemical Company in Midland, Michigan has a unique and challenging opportunity for an Informatics Post Doctoral Fellow to conduct research within our Systems Toxicology program.
 
TERC focuses on research that defines and addresses potential health and environmental risks from Dow products and operational processes. Its scientists build both new capabilities and professional expertise necessary to meet regulatory requirements and to address emerging issues such as children’s health, the impact of genomic sciences on toxicology and risk assessment, and the bioavailability of contaminants in soil and sediments. Most importantly, they continue to develop and execute strategies to ensure that science-based, risk management policies remain the basic paradigm for chemicals management and regulation, globally. 
 
The Post Doctoral fellow will participate in a research program that is developing in vitro, molecular, and computational approaches for use in early stage toxicity evaluation of new chemical products in support of “greener”, more sustainable chemical development.
 
Key activities of the Postdoctoral Research Fellow are likely to include the following, contingent upon individual interests and skills:

• Development of computational models to predict toxicity based on a variety of information sources, such as chemical structure, in vitro data generated in human cell line, reporter gene and zebrafish embryo models, publically available high throughput data (e.g., EPA ToxCast program), and toxicogenomic data.
• Analysis of genomic signatures using approaches such as Connectivity Mapping, and application of these methods to evaluate categories of chemicals thought to share a common mechanism of action. 
• Mining of government-generated high throughput data (e.g. EPA ToxCast program) to incorporate into tiered testing approaches. 
• Participate in ongoing research collaborations between Dow and laboratories such as US EPA, other companies, and/or research institutes. 
• Gain experience and general knowledge about chemical safety assessment as conducted in one of world’s leading industrial toxicology laboratories.
• Publish and present research at internal/external meetings and in peer-reviewed journals. 

 
A PhD is the minimum education requirement for this position, preferably in Toxicology, Molecular Toxicology, Informatics, Computational Biology, Systems Biology or other related disciplines.
 
Candidates must have had informatics as a focus of their PhD research, preferably in genomics or toxicogenomics.
 
The following additional skills or responsibilities are preferred:

• Advanced skills in informatics and statistical analysis
• Experience in predictive model development
• Strong background in chemistry, particularly organic chemistry
• Knowledge of basic cellular and molecular mechanisms of toxicity
• Strong written and oral communication skills that allow dissemination of complex technical issues in a clear, concise manner
• Demonstrated ability to work independently 

 
 
About Dow
Dow (NYSE: DOW) combines the power of science and technology to passionately innovate what is essential to human progress. The Company connects chemistry and innovation with the principles of sustainability to help address many of the world's most challenging problems such as the need for clean water, renewable energy generation and conservation, and increasing agricultural productivity. Dow's diversified industry-leading portfolio of specialty chemical, advanced materials, agrosciences and plastics businesses delivers a broad range of technology-based products and solutions to customers in approximately 160 countries and in high growth sectors such as electronics, water, energy, coatings and agriculture. In 2011, Dow had annual sales of $60 billion and employed approximately 52,000 people worldwide. The Company's more than 5,000 products are manufactured at 197 sites in 36 countries across the globe. References to "Dow" or the "Company" mean The Dow Chemical Company and its consolidated subsidiaries unless otherwise expressly noted. More information about Dow can be found at http://www.dow.com/.
 
Dow is an equal employment opportunity employer. We offer a competitive salary and benefit package.
 
To apply for this position, visit https://dow.taleo.net/careersection/10020/jobdetail.ftl?job=1210944