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Previous DRSG Seminars – 2000-2010

The Use and Misuse of Dose Thresholds in Risk Assessment
Kenny Crump, Louisiana Tech University
September 7, 2010

Microbial Dose-Response & Its Use in Estimating the Benefits of EPA’s Drinking Water Rules
Jeff Swartout, U.S. EPA National Center for Environmental Assessment,
Mike Messner, U.S. EPA Office of Ground Water and Drinking Water, and
Stig Regli, U.S. EPA Office of Ground Water and Drinking Water
August 3, 2010

Threshold of Toxicological Concern (TTC)
Michael Laufersweiler, Procter & Gamble Central Product Safety, and
Stephen Olin, ILSI Research Foundation
March 3, 2010

High Throughput Screening for Hazard and Risk of Environmental Contaminants
David J. Dix, U.S. EPA
October 6, 2009

Using Empirical Data on Toxicity Pathways in the Prediction of Responses at Low Doses
Paul Price, Dow Chemical Company
September 1, 2009

Chemical-Specific Adjustment Factors: The IPCS Approach to Developing Non-Default Values for Inter and Intra-species Extrapolation
John Lipscomb, U.S. EPA,
and
Categorical Regression Modeling of Multiple Effects from Chemical Mixture Exposures in Cumulative Risk Assessment
Linda Teuschler, U.S. EPA
June 9, 2009

Discussion of National Academy of Sciences Report - Science and Decisions: Advancing Risk Assessment
Michael Dourson, TERA
March 3, 2009

The BMD Approach in Europe: Recent Developments in Acceptance, and Some Specific Views
Wout Slob, RIVM
September 2, 2008

Dose-Response Analysis in Environmental Risk Assessment:
Where are we, and where are we going?

Weihsueh Chiu, U.S. EPA
June 3, 2008

Characterizing Dose-Response Model Uncertainty Using Model Averaging
Matthew Wheeler, NIOSH
March 5, 2008

Radiation Cancer Risk Estimates and the Use of the Linear Nonthreshold Model
Julian Preston, U.S. EPA
September 11, 2007

Toxicokinetics and Risk Assessment, a text
John Lipscomb, U.S. EPA
June 5, 2007

PBPK Modeling for Acrylamide: Relating Mechanisms, Adducts, Metabolites, and Kinetics to Risk Assessment
Daniel R. Doerge and John F. Young, NCTR, U.S. FDA
March 6, 2007

Intraspecies variability in toxicant effects: Nuisance, nemesis or sustenance for risk assessment?
Robert MacPhail, U.S. EPA
September 5, 2006

Mode of Action in Assessing the Human Relevance of Animal Tumors: An EPA Perspective
Vicki Dellarco; Anna Lowit, U.S. EPA
February 6, 2006

Inhalation Toxicity of Single Wall Carbon Nanotubes
Robert R. Mercer, NIOSH Unique Properties of Nanomaterials that Raise Concerns for Toxicology Research
Jo Anne Shatkin, The Cadmus Group
June 6, 2006

Computational Systems Biology and Dose Response Assessment
Mel Andersen, CIIT Centers for Health Research
September 6, 2005

Age-Related Differences in Susceptibility to Carcinogenesis—Human Risk Inferences from an Analysis of Animal Bioassay Data
Dale Hattis, Clark University
June 7, 2005

Update on International Initiatives for Chemical Specific Adjustment Factors and Physiologically Based Pharmacokinetic (PBPK) Models for Use in Risk Assessment
Bette Meek, Health Canada
March 1, 2005

Benchmark-Dose Shopping with Proper Confidence
Walter Piegorsch, University of South Carolina
September 7, 2004

Dose-Dependent Transitions in Toxic Mechanisms: Implications for Risk Assessment
David Gaylor, Gaylor and Associates
June 1, 2004

Arsenic: Proposed Mechanisms and Risk Assessment Implications
Michael Luster, NIOSH
March 2, 2004

Cumulative Risk Assessment for Chemical Mixtures
James Chen, U.S. National Center for Toxicological Research
September 2, 2003

Dose-Response Curves in Chemical Carcinogenesis
William Waddell, University of Louisville
June 3, 2003

Bystanders, Adaptive Responses and Genomic Instability – Potential Modifiers of Low-Dose Cancer Responses
Julian Preston, U.S. EPA
March 4, 2003

Model Uncertainty in Microbial Risk Assessment
Ravi Varadhan, Johns Hopkins University
September 3, 2002

Computational Modeling of Mechanisms of Nonmonotonic Dose-Response: Androgen Receptor Activation and Tumor Incidence
Rory Conolly, CIIT Centers for Health Research
June 4, 2002

Variability in Dose-Response Assessments
Wout Slob, RIVM
March 5, 2002

Dioxin: Dose-Response for Acute Effects
Jim Wilson, Resources for the Future
September 4, 2001

Assessment of Risks to Children from Exposure to Environmental Agents
Gary Kimmel, U.S. EPA
Chemical Mixtures Risk Assessment: Current Approaches and Emerging Issues
Peter Robinson, ManTech
Integrating Toxicokinetics and Toxicodynamics in Mechanistic Risk Assessment
Jeff Swartout, U.S. EPA
Risks from Various Exposure Durations
Ron Brown, FDA
June 4, 2001

Compound Specific Adjustment Factors – An International Perspective
Bette Meek, Health Canada
April 3, 2001

A Model for the Development of Tolerable Upper Intake Levels for Nutrients
Elizabeth Reese & Joseph Rodricks, The Life Science Consultancy;
Steve Taylor, University of Nebraska
October 3, 2000

Microbial Dose-Response Modeling: Surrogate Dose-Response Models for the Foodborne Pathogen E. coli O157:H7
Peg Coleman, USDA
June 6, 2000

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Revised November 22, 2010