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Dose-Response Modeling: Benchmark Dose Modeling Approach’s Using EPA’s BMDS Online and NIEHS’ ToxicR

Thursday, December 8, 2022 with J. Allen Davis, Matthew Wheeler, Jay Zhao, Andy Shapiro, Todd Blessinger and Jeff Gift (8:30AM-5:30PM)

For years, EPA’s Benchmark Dose Software has been available as a stand-alone Windows desktop application for the dose-response analysis of toxicological data for risk assessment. In addition to the updated BMDS Excel release in 3.3; the EPA and NIEHS have expanded dose-response capabilities to Online (Web) and an R-package (free software for statistical computing) environments. BMDS-Online reimplements the existing BMDS software in a web-based application, allowing users to run BMDS on any computer with access to the internet. ToxicR is a R-based Bayesian modeling platform developed by NIEHS/NTP that “untethers” BMDS and other models from standard parameterizations, expanding its capabilities for research applications.

This workshop will cover dose-response analyses (frequentist and Bayesian); participants will learn and practice (through hands-on exercises) dose-response modeling of dichotomous and continuous response data using BMDS-Online. Following these introductory analyses, participants will learn and practice the use of Bayesian models, including the application of a Bayesian framework for model averaging using ToxicR. Participants will explore model averaging approaches for dichotomous and continuous data, including new model averaging capabilities for continuous data that include the European Food Safety Authority’s (EFSA) suite of continuous models currently only available in ToxicR.

The research functionality and modeling capacity of the ToxicR platform will be demonstrated. Hands-on exercises in ToxicR will be provided. Participants will be shown how to modify prior assumptions and perform sensitivity analyses to investigate the default prior’s effect on a given analysis. Additional features of the package that allow for scripted batch processing, advanced graphics, and custom BMD analysis will also be highlighted.